CodeBreaK 200 Confirms Sotorasib’s Superiority Compared to Docetaxel, Investigator Says
Erin JungmeyerIn a Q&A with ILCN, Dr. Melissa Johnson recaps the trial’s positive results—and surprises—and discusses the potential roles sotorasib and other drugs in its class may play in treating KRAS G12C+ NSCLC. Read more
Tobacco Smoking-Related Mutational Signatures: Is it Time to Move on From Patient-Reported History?
Sophie M. Ernst, MD+more
Study highlights limitations of relying solely on clinical smoking history, and findings suggest tobacco smoking-related mutational signatures could potentially guide molecular testing and optimize patient stratification in clinical trials. Read more
Increasing Evidence Demonstrates the Usefulness of ctDNA
Christian Rolfo, MD, PhD, MBA, Drhc+more
LALCA participants recap how the field of liquid biopsy continues to grow—from new biomarkers to new frontiers in early cancer detection. Read more
ILCN Editor Dr. Corey J. Langer reflects on highlights from the past year and looks at the year to come. Read more
Guideline-Concordant Surgery, Adjuvant Therapy, and the Promise of Curative-Intent Lung Cancer Surgery: What Are We Up Against?
Osa Ogbeide, MD+more
In a “tale of two trials,” Drs. Ogbeide and Osarogiagbon use insights from the ALCHEMIST trial population to try to understand outcomes disparities between North America and Japan. Read more
Targeted Therapies Expanding for MET Dysregulation in NSCLC
Erin JungmeyerDuring ACLC 2022, Dr. Noemi Reguart reviewed the data for MET-targeting TKIs and monoclonal antibodies for patients with METex14 skipping mutations, MET amplification, and MET overexpression. Read more
Undruggable No More: KRAS Experts Review What is Known—and Unknown—About This Challenging Alteration
Lei Deng, MD+more
Beyond sotorasib, dozens of small molecule inhibitors are being explored to target this oncogenic driver. Get up to date as researchers from Roswell Park Comprehensive Cancer Center summarize the KRAS trial landscape. Read more
HER2 Mutations Present Unique Challenges in NSCLC
Stephanie P.L. Saw, MD+more
Drs. Stephanie Saw and Daniel Tan stress the importance of understanding the intricacies of HER2 testing in non-small cell lung cancer to optimize patient selection. Read more
Growing Body of Evidence Highlights Potential Applications for Liquid Biopsy in Clinical Practice
Erin JungmeyerDuring a lecture at NACLC 22, Dr. Christian Rolfo illustrated how ctDNA could be used to monitor progression and inform treatment decisions. Read more
When Perfect is the Enemy of Good: Investigators Compare Rigorous Clinical Trial Data to Real-World Experience
Kamya Sankar, MD+more
Using a real-world cohort of US veterans, researchers examine the effectiveness of durvalumab consolidation in unresectable stage III NSCLC. Read more